Padmavati rao biography template

2018 film directed by Sanjay Leela BhansaliTemplate:SHORTDESC:2018 film directed by Sanjay Leela Bhansali

This article is about the film. For other uses, see Padmavati.

Template:Pp-pc1

Padmaavat

Padmaavat is a 2018 IndianHindi-languagehistorical drama film directed by Sanjay Leela Bhansali. Based on the epic poemof the same name by Malik Muhammad Jayasi, it stars Deepika Padukone as Rani Padmavati, a Rajput queen known for her beauty, wife of Maharawal Ratan Singh, played by Shahid Kapoor. Sultan Alauddin Khalji, played by Ranveer Singh, hears of her beauty and attacks her kingdom to enslave her. Aditi Rao Hydari, Jim Sarbh, Raza Murad, and Anupriya Goenka featured in supporting roles.

TBA

At the 64th Filmfare Awards, Padmaavat received a leading 18 nominations, including Best Film, Best Director (both for Bhansali), Best Actress (Padukone) and Best Actor (Singh), and won 4 awards, including Best Actor (Critics) (Singh). It also won 3 National Film Awards, including Best Music Direction (Bhansali).

Plot[]

In 13th-century Afghanistan, Khalji ruler, Jalal-ud-din Khalji plans to take over the throne of Delhi. His evil nephew Alauddin Khalji asks for Jalaluddin's daughter Mehrunisa's hand in marriage. Their wedding is organised, but on the night of the event, Alauddin engages in adultery with anoth

2018 film directed by Sanjay Leela BhansaliTemplate:SHORTDESC:2018 film directed by Sanjay Leela Bhansali

This article is about the film. For other uses, see Padmavati.

Template:Pp-pcTemplate:Use Indian English

Padmaavat

Padmaavat is a 2018 IndianHindi-languagehistorical drama film directed by Sanjay Leela Bhansali. Based on the epic poemof the same name by Malik Muhammad Jayasi, it stars Deepika Padukone as Rani Padmavati, a Sinhalese-bornRajput queen known for her beauty, wife of Maharawal Ratan Singh, played by Shahid Kapoor. Sultan Alauddin Khilji, played by Ranveer Singh, hears of her beauty and attacks her kingdom to enslave her. Aditi Rao Hydari, Jim Sarbh, Raza Murad, and Anupriya Goenka featured in supporting roles.

With a production budget of Template:INRConvert–Template:INRConvert, Padmaavat is one of the most expensive Indian films ever made. Initially scheduled for release on 1 December 2017, the film faced numerous controversies. Amid violent protests, its release was indefinitely delayed. The Central Board of Film Certification later approved the film with few changes, which includes the addition of multiple disclaimers and a change from its original title Padmavati. It was rescheduled for release on 25 January 2018 in 2D, 3D and IMAX 3D formats, making it the first Indian film t

Published in final edited form as: Prog Mol Biol Transl Sci. 2017 Mar 22;147:1–73. doi: 10.1016/bs.pmbts.2017.02.005

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the degradation of various proteins in the extracellular matrix (ECM). Typically, MMPs have a propeptide sequence, a catalytic metalloproteinase domain with catalytic zinc, a hinge region or linker peptide, and a hemopexin domain. MMPs are commonly classified on the basis of their substrates and the organization of their structural domains into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs. MMPs are secreted by many cells including fibroblasts, vascular smooth muscle (VSM) and leukocytes. MMPs are regulated at the level of mRNA expression and by activation of their latent zymogen form. MMPs are often secreted as inactive proMMP form which is cleaved to the active form by various proteinases including other MMPs. MMPs cause degradation of ECM proteins such as collagen and elastin, but could influence endothelial cell function as well as VSM cell migration, proliferation, Ca signaling and contraction. MMPs play a role in tissue remodeling during various physiological processes such as angiogenesis, embryogenesis, morphogenesis and wound repair, as well as in pathological conditions such as myocardial infarction, fibrotic disorders, osteoarthritis, and cancer. Increases in specific MMPs could play a role in arterial remodeling, aneurysm formation, venous dilation and lower extremity venous disorders. MMPs also play a major role in leukocyte infiltration and tissue inflammation. MMPs have been detected in cancer, and elevated MMP levels have been associated with tumor progression and invasiveness. MMPs can be regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs), and the MMP/TIMP ratio often determines the extent of ECM