Mella frewen biography of alberta

from the international community of women (and their allies) in Science, Technology, Engineering, and Mathematics (STEM)

We the signatories of this statement are writing to express our grief and outrage for the tragic death of the 22-year old Iranian woman, Mahsa Amini, who was taken into custody by Iranian state morality guards for allegedly violating gender-discriminatory laws regarding hair covering.

We support and stand with Iranian women and their allies who are protesting in the streets and demanding their fundamental human right to choose their own dress without coercion, and the right to bodily integrity.

Furthermore, we express our concern for the safety and the freedom of speech of those, from the civil society or from academia, who are advocating for human rights and the values of gender equity.

Finally, we categorically denounce any persecution or use of violence against Iranian protesters, and condemn government-sanctioned violence in general and gender-based violence in particular.

2,630 Signatories

1. Donna Strickland
   Professor, Nobel Laureate 2018, Physics
   University of Waterloo, Canada
2. Sheldon Glashow
   Professor, Nobel Laureate 1979, Physics
   Retired, USA
   
3. Samaya Nissanke
   Associate Professor, Astrophysics
   GRAPPA, University of Amsterdam, The Netherlands
4. Emilie Ringe
   Professor of Synthetic and Natural Nanomaterials
   Materials Science, University of Cambridge, UK
5. Camilla Parmeggiani
   Associate Professor, Industrial Chemistry
   University of Florence, Italy
6. Julia Tjus
   Professor, Physics and Astrophysics
   Ruhr-Universität Bochum, Germany
7. Maria Sibilia
   Prof. and Director, Center for Cancer Research, Cancer Research
   Medical University of Vienna, Austria
8. Katelin Schutz
   Assistant Professor, Particle Astrophysics
   McGill University, Canada
9. Rachel Roberts
   Professor, Mathematics
   Washington University in S

AFM71 cover_Layout 1 01/02/2011 10:19 Page 1

The business and financing of airline operations

READY FOR TAKE-OFF: START-UP AIRLINES AND LESSORS

PLUS: n EXAMINING THE MARKET FOR LOW-COST LONG-HAUL n AN UPDATE FROM IATA ON THE FUTURE OF BIOFUELS n THE CASE FOR LOW-COST CARGO n AIR TRAFFIC MANAGEMENT: MOVING FORWARD

January-February 2011 Issue 71

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Why take a step in the dark when you could take a LEAP into the future?

Only one engine manufacturer brings nearly half a billion hours of experience to developing leading edge technology built on a track record of unrivalled reliability in its thrust class. The future holds no fears when you choose CFM.* www.cfm56.com/xpower

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AFM71 TOC restyle_TOC 28/01/2011 16:21 Page 2

C O N T E N T S

The business and financing of airline operations

January-February 2011 • Issue 71 EDITOR Mary-Anne Baldwin: Mary-Anne.Baldwin@ubmaviation.com Tel: +44 (0) 207 579 4843

JOURNALIST Alex Derber: aderber@ubmaviation.com

CONTRIBUTORS Chris Kjelgaard, Bernard Fitzsimons, Scott Hamilton, Paul Steele and Martin Roebuck.

DESIGN & PRODUCTION Kalven Davis: Kalven.Davis@ubmaviation.com Tel:+44 (0) 207 579 4851

DISPLAY ADVERTISING Simon Barker: Simon.Barker@ubmaviation.com Alan Samuel: Alan.Samuel@ubmaviation.com Tel: +44 (0) 207 579 4845/46

NEWS ROUND-UP

TRADING, LEGAL & FINANCE:

2 The latest on deals, mergers appointments and more.

34 The new generation of aircraft lessors: Is this a revolution?

FOCUS: 12 Start-up airlines: Clearing for take-off Launching an airline and ensuring its profitability is not easy, as many failed startups have shown. Chris Kjelgaard investigates Allegiant Air, Feel Air and Porter Airlines to examine the factors that new airlines should take into account

Abstract

For many genetic disorders, there are no specific metabolic biomarkers nor analytical methods suitable for newborn population screening, even where highly effective preemptive treatments are available. The direct measurement of signature peptides as a surrogate marker for the protein in dried blood spots (DBSs) has been shown to successfully identify patients with Wilson Disease (WD) and three life-threatening inborn errors of immunity, X-linked agammaglobulinemia (XLA), Wiskott–Aldrich syndrome (WAS), and adenosine deaminase deficiency (ADAD). A novel proteomic-based multiplex assay to detect these four conditions from DBS using high-throughput LC-MS/MS was developed and validated. The clinical validation results showed that the assay can accurately identify patients of targeted disorders from controls. Additionally, 30,024 newborn DBS samples from the Washington State Department of Health Newborn Screening Laboratory have been screened from 2022 to 2024. One true presumptive positive case of WD was found along with three false positive cases. Five false positives for WAS were detected, but all of them were premature and/or low-birth-weight babies and four of them had insufficient DNA for confirmation. The pilot study demonstrates the feasibility and effectiveness of utilizing this multiplexed proteomic assay for newborn screening.

Keywords: Wilson Disease, Wiskott–Aldrich syndrome, X-linked agammaglobulinemia, adenosine deaminase deficiency, newborn screening, proteomics, peptide, mass spectrometry

1. Introduction

The successful introduction of newborn screening (NBS) for phenylketonuria in dried blood spots (DBSs) by the pioneering work of Dr. Robert Guthrie in the early 1960s has been the catalyst for establishing population-based newborn screening in the United States for over 30 disorders to date [1]. There has been increasing global interest in expanding newborn screening panels to include more genetic diseases due to significant advances in